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2 edition of Drug action on anxiety models with special reference to serotonergic mechanisms. found in the catalog.

Drug action on anxiety models with special reference to serotonergic mechanisms.

Martyn A. E. Critchley

Drug action on anxiety models with special reference to serotonergic mechanisms.

by Martyn A. E. Critchley

  • 340 Want to read
  • 36 Currently reading

Published by AstonUniversity. Department of Pharmaceutical Sciences in Birmingham .
Written in English


Edition Notes

Thesis (PhD) - Aston University, 1988.

ID Numbers
Open LibraryOL13875902M

May 13,  · This volume reviews the current state of research within the behavioral pharmacology of 5-HT. The book opens exciting new approaches to the interdisciplinary study of behavior and pharmacology with special reference to ethology, endocrinology, neuroanatomy and comparative aspects of drug action, and notes new developments in therapeutic drugs of the astonmartingo.com by: Jun 23,  · New mechanisms of action found for drugs used to treat anxiety disorders; New mechanisms of action found for drugs used to treat anxiety disorders. "The successful implementation of an experimentally inducible anxiety model in healthy subjects will facilitate the development of innovative anxiolytics in the future, as the testing of active.

Mennini T., Caccia S., Garattini S. () Mechanism of action of anxiolytic drugs. In: Jucker E., Meyer U. (eds) Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques. Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques, vol Birkhäuser Cited by: Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. They act by antagonizing the α 2-adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C, but also .

Behavioural and biochemical studies on the effects of acute and chronic administration of antidepressant drugs on central serotonergic receptor mechanisms. In S. Langer, T. Takahashi, T. Segawa and M. Briley (eds.), New Vistas in Depression, Pergamon Press, –19 Google ScholarCited by: Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats Yan Li, Kasper F. Raaby, Connie Sánchez, Maria E. GulinelloCited by:


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Drug action on anxiety models with special reference to serotonergic mechanisms by Martyn A. E. Critchley Download PDF EPUB FB2

A study has been made of drugs acting at 5-HT receptors on animal models of anxiety. An elevated X-maze was used as a model of anxiety for rats and the actions of various ligands for the 5-HT receptor, and its subtypes, were examined in this model.

5-HT agonists, with varying affinities for the 5-HT receptor subtypes, were demonstrated to have anxiogenic-like astonmartingo.com: Martyn A.E.

Critchley. Drug action on anxiety models with special reference to serotonergic mechanisms Author: A study has been made of drugs acting at 5-HT receptors on animal models of anxiety.

An elevated X-maze was used as a model of anxiety for rats and the actions of various ligands for the 5-HT receptor, and its subtypes, were examined in this model. 5-HT Cited by: 1. Importantly, however, azapirones do not display affinity for I^Hlbenzodiazepine binding sites in vitro (Taylor et al., ) and exert their action via benzodiazepine-independent mechanisms (Eison and Eison, ).

5-HT and anxiety 53 The anticonflict action of the azapirones buspirone and gepirone appears to be dependent upon intact serotonergic innervation as this effect was significantly attenuated in animals with lesions of serotonergic neurons Cited by: The effects of AP, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in ratsCited by: 4.

The effects of AP, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats Article (PDF Available) in Journal of Pharmacological Sciences (1) Mar 13,  · These chiefly pertain to molecular neuropharmacology.

This chapter is devoted to illuminating and discussing such questions in the context of preclinical experimental approaches for studying mechanisms of action of serotonergic psychedelics, classic and astonmartingo.com by: 3.

This volume reviews the current state of research within the behavioral pharmacology of 5-HT. The book opens exciting new approaches to the interdisciplinary study of behavior and pharmacology with special reference to ethology, endocrinology, neuroanatomy and comparative aspects of drug action, and notes new developments in therapeutic drugs of the future.

Although buspirone has a variety of pharmacological activities involving serotonin, noradrenaline and dopamine, the demonstration that the anticonflict properties of this drug were lost after serotonergic lesion suggested the importance of this monoamine in anxiety (Eison et al., ).

The original trend to do this selectively (e.g., with SSRIs or selective serotonin reuptake inhibitors) has given way to combining various additional pharmacologic mechanisms with SERT inhibition, including dual actions by single drugs (e.g., SNRIs or serotonin norepinephrine reuptake inhibitors).

Serotonin acts in the prelimbic part of the medial prefrontal cortex, via 5-HT 2A receptors, to activate layer V pyramidal neurons, which are known to project back to the dorsal raphe nucleus to inhibit anxiety-promoting serotonergic neurons in a model of learned helplessness (not shown), thus demonstrating how the afferent thermosensory system may influence “top-down” regulation of depression circuits, for example during cognitive behavioral therapy Cited by: JPM Vol.

29, No. 3 June An Assessment of the Elevated X-Maze for Studying Anxiety and Anxiety-Modulating Drugs S.

Handley and J. McBlane Pharmaceutical Sciences Institute, Aston University, Birmingham, England, United Kingdom The elevated X-maze has strong claims to validity as an animal model of anxiety, both in theoretical basis and drug astonmartingo.com by: Oct 01,  · During the past 25 years there has been a dramatic increase in the knowledge about noradrenergic and serotonergic mechanisms in stress response, PTSD and more recently in resilience and this knowledge has justified the use of antidepressants with monoaminergic mechanisms of action for patients with astonmartingo.com by: Antidepressant drugs, particularly serotonin reuptake inhibitors and serotonin receptor modulators, are effective for a wide variety of anxiety and depressive disorders.

The impact on both anxiety and depression may be a result of an effect on a common set of physiologic targets relevant to the general distress astonmartingo.com by: CNS-related (side-)effects of beta-blockers with special reference to mechanisms of action. Koella WP. beta-Adrenoreceptor antagonists are liable to produce behavioural side-effects such as drowsiness, fatigue, lethargy, sleep disorders, nightmares, depressive moods, and astonmartingo.com by: This chapter is devoted to illuminating and discussing such questions in the context of preclinical experimental approaches for studying mechanisms of action of serotonergic psychedelics, classic.

Depression is associated with reduced levels of monoamines in the brain. Noradrenergic and specific serotonergic antidepressants (NaSSAs) have a dual mechanism of action that increases the concentration of 5-HT and noradrenaline in the synaptic cleft to within the normal range.

Sep 28,  · A variety of serotonin (5-HT) receptors, especially 5-HT2A, 5-HT1A, 5-HT6, 5-HT7, and 5-HT2C, have been postulated to contribute to the mechanism of action of atypical antipsychotic drugs (APDs), Serotonergic Mechanisms as Targets for Existing and Novel Antipsychotics | SpringerLinkCited by: Treatment with medications affecting dopaminergic and serotonergic mechanisms: Effects on fluency and anxiety in persons who stutter Article in Journal of Fluency Disorders 30(4) Abstract: The current generation of antidepressant drugs acts predominantly by targeting the serotonin transporter (SERT).

The original trend to do this selectively (e.g., with SSRIs or selective serotonin reuptake inhibitors) has given way to combining various additional pharmacologic mechanisms with SERT inhibition, including dual actions by single drugs (e.g., SNRIs or serotonin.

Apr 01,  · • The physical symptoms of severe anxiety are similar to those of fear (such as tachycardia, sweating, trembling, and palpitations) and involve sympathetic activation.

Anxiety 4. Antianxiety drugs • The anxiolytic-sedative drugs differ from anti psychotics, and more closely resemble sedative-hypnotics. The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders Jocelien D.

A. Olivier 1,2, Christiaan H. Vinkers 3,4 and Berend Olivier 3,5* 1 Department of, Women’s and Children’s Health, Uppsala University, Uppsala, SwedenCited by: Additional evidence of the role of monoamines in pain modulation comes from studies of antidepressant administration in animal models of pain.

In comparison of drugs inhibiting serotonin or norepinephrine reuptake inhibition (desipramine, reboxetine, fluoxetine and paroxetine), the norepinephrine reuptake inhibiting drugs desipramine and Cited by: The effects of serotonergic and antiserotonergic drugs on the hind limb flexor reflex (measured as a contraction of musculus tibialis anterior or as a flexion of the paw) in the spinal rat was studied.

All serotonergic drugs used (Lhydroxytryptophan, L-tryptophan, LSD, fenfluramine, p-chloro-amphetamine) stimulate the flexor astonmartingo.com by: