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Friday, July 17, 2020 | History

3 edition of Interleukin-5 and its receptor system found in the catalog.

Interleukin-5 and its receptor system

Kiyoshi Takatsu

Interleukin-5 and its receptor system

from genes to disease

by Kiyoshi Takatsu

  • 243 Want to read
  • 1 Currently reading

Published by Springer-Verlag, R.G. Landes in New York, Austin .
Written in English

    Subjects:
  • Interleukin-5.,
  • Interleukin-5 -- Receptors.,
  • Interleukin-5 -- Pathophysiology.,
  • Interleukin-5 -- physiology.,
  • Receptors, Interleukin -- physiology.,
  • Immunity, Cellular.

  • Edition Notes

    Includes bibliographical references and indexes.

    Other titlesInterleukin five and its receptor system.
    StatementKiyoshi Takatsu.
    SeriesMolecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)
    Classifications
    LC ClassificationsQR185.8.I56 T35 1995
    The Physical Object
    Pagination167 p. :
    Number of Pages167
    ID Numbers
    Open LibraryOL1275858M
    ISBN 101570592330, 3540592121
    LC Control Number95007453

    Structure and function of interleukin-4 and its receptor. Pages Puri, Raj K. Preview Buy Chap95 € Interleukin An overview. Pages Takatsu, Kiyoshi *immediately available upon purchase as print book shipments may be delayed due to the COVID crisis. ebook access is temporary and does not include ownership of. 1 day ago  Introduction: Colorectal Cancer (CRC) accounts for 9% of cancer deaths globally. Hormonal pathways play important roles in some cancers. This study investigated the association of CRC expression of neurotensin (NTS), NTS receptors 1 and 3 (NTSR1 and NTSR3) and clinical outcomes. Methods: A prospective cohort study which quantifies the protein expression .

    Because IL-5 expression has been shown to regulate the expression of its own receptor α-subunit (Tavernier et al., ), we hypothesized that progenitor cells from asthmatic patients synthesize and release IL-5 in an autocrine fashion to act on IL-5Rα on CD34+cells, leading to a preferential development into the eosinophilic lineage. The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5).

    Search the world's most comprehensive index of full-text books. My library. Interleukin-5 and Its Receptor System: From Genes to Disease (Molecular Biology Intelligence Unit) Jul 1, by Kiyoshi Takatsu Hardcover.


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Interleukin-5 and its receptor system by Kiyoshi Takatsu Download PDF EPUB FB2

Interleukin-5 and Its Receptor System: From Genes to Disease (Molecular Biology Intelligence Unit) [Takatsu, Kiyoshi, Ph.D.] on *FREE* shipping on qualifying offers.

Interleukin-5 and Its Receptor System: From Genes to Disease (Molecular Biology Intelligence Unit)Author: Kiyoshi Takatsu. Following a summary of developments that led to the molecular characterization of interleukin-5, this volume describes recent advances in the study of its structure, physiological functions and mode of receptor-mediated signalling.

The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and :   Publisher Summary The chapter summarizes advances in interleukin-5 (IL-5) and IL-soluble receptor (IL-SR) research in the study of structure, physiologic functions, and the unique modes of receptor-mediated signaling.

The chapter also discusses the pathophysiology of aberrant expression of IL-5 and its by: Tavernier J, Devos R, Cornelis S, Tuypens T, Van der Heyden J, Fiers W, Plaetinck G. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF.

CellPubMed CrossRef Google ScholarCited by: 8. Interleukin 5 and its receptor in nasal inflammatory diseases. Philippe Gevaert (BE). Department of Otorhinolaryngology, Ghent University Hospital.

Belgium. The interleukin 5 receptor (IL-5R) is a complex consisting of and subunits. The -subunit is ligand-specific, and binds this ligand with intermediate affinity in man.

Association with the -subunit leads to a high affinity receptor. Abstract Human interleukin 5 (hIL5) and soluble forms of its receptor alpha subunit were expressed in Drosophila cells and purified to homogeneity, allowing a detailed structural and functional analysis.

B cell proliferation confirmed that the hIL5 was biologically active. Interleukin-5 is a cytokine that belongs to the β common chain family [together with interleukin-3 and granulocyte-monocyte colony-stimulating factor (GM-CSF)] and binds an heterodimer receptor composed by the specific subunit interleukin-5Rα and common β subunit βc [3,38] (Fig.

​(Fig.4).4). In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment.

Chapter Insights into the Pathogenesis of Asthma and Other Eosinophil-Mediated Diseases from Antagonists of Interleukin-5 and its Receptor. Chapter Interleukin-5 Receptor-Directed Strategies. Chapter Therapeutic Approaches Targeting Siglecs. Chapter Targeting the FIP1L1–PDGFRα and Variant PDGFRα and PDGFRβ Fusion Kinases.

Interleukin-5 (IL-5) is an essential cytokine for eosinophil differentiation and survival. IL-5 blockade by monoclonal antibodies (mepolizumab, reslizumab) partially reduces the number of circulating and tissue eosinophils and associated exacerbations in patients with eosinophilic asthma. Interleukin-5 (IL-5) CD4+T cells (Th2) produce IL-5, and its principal targets are B cells.

It causes B-cell growth factor and differentiation and IgA selection. Besides, causes eosinophil activation and increased production of these innate immune cells. Interleukin-6 (IL-6) T and B lymphocytes, fibroblasts and macrophages make IL The IL-5 receptor is composed of an α and a βc chain.

The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL3) and granulocyte-macrophage colony-stimulating factor (GM-CSF).

Glycosylation of the Asn residue of the Rα subunit appears to be essential for binding of IL IV IL-5 receptor structure/isoforms/distribution The IL-5 receptor consists of α and β chains that, when bound to IL-5 ligand, activate a series of signal transduction cascades.

The β chain of the IL-5 receptor is also utilized by the IL-3 and GM-CSF receptors and is therefore known as the βc, or common, β chain. With more than expert authors from 22 different countries, the Encyclopedia of Immunology, Second Edition is the largest comprehensive reference source of current immunological knowledge available.

It provides a broad scope and high level of expertise to the many aspects of the field of immunology and related areas, including microbiology, virology, and parasitology.

Interleukin An overview. Kiyoshi Takatsu. Pages Interleukin A comprehensive review from the early embryonic stage to maturity and are responsible for the normal function of virtually every organ system.

Furthermore, virtually all disease states have been associated, at least in part, with cytokine aberrations. Identification of the second subunit of the murine interleukin-5 receptor: interleukin-3 receptror-like protein, AIC2B is a component of the high-affinity interleukin-5 receptor.

EMBOJ. – PubMed Google Scholar. Receptor activation by the haematopoietic growth factor proteins interleukin 5 (IL-5) and granulocyte-macrophage colony-stimulating factor (GM-CSF) leads to.

The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of.

Interleukin-5 (IL-5) is a secreted glycoprotein that belongs to the alpha -helical group of cytokines (1 ‑ 3). Unlike other family members, it is present as a covalently linked antiparallel dimer (4, 5).

The cDNA for human IL-5 encodes a signal peptide and a amino acid (aa) mature protein. The Linked Data Service provides access to commonly found standards and vocabularies promulgated by the Library of Congress. This includes data values and the controlled vocabularies that house them.

Datasets available include LCSH, BIBFRAME, LC Name Authorities, LC Classification, MARC codes, PREMIS vocabularies, ISO language codes, and .Interleukin-5 (IL-5) mediates pleiotropic functions in various types of cells through its specific receptor (IL-5R) which is composed of two distinct subunits, α and β.Interleukin (IL), any of a group of naturally occurring proteins that mediate communication between cells.

Interleukins regulate cell growth, differentiation, and motility. They are particularly important in stimulating immune responses, such as inflammation.

Interleukins are .